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With new refrigerants come new challenges. When you mix high-pressure refrigerants with lower pressure refrigerants, the refrigerants boil off at different temperatures at the same pressure and this is what we call glide.
Example R407F is a mix of R32, R125, and R134a (30%/30%/40%)
R32 @ 80 psig = ~20F
R125 @ 80 psig = ~30F
R134 @ 80 psig = ~76F
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